Decreased alpha globine mRNA in nucleated red cell precursors in alpha thalassemia
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منابع مشابه
Decreased a Globin mRNA in Nucleated Red Cell Precursors in a Thalassemia
The a thalassemias are associated with a decrease in a chain synthesis. Hemoglobin H (HbH) disease is a moderately severe form of a thalassemia characterized by the production of 5%-20% of HbH, while a thalassemia trait is a milder form of a thalassemia. In two patients with HbH disease, the ratio of a chain synthesis to fi chain synthesis (a/fl ratio) was decreased in both bone marrow cells an...
متن کاملDecreased a Globin mRNA in Nucleated Red Cell Precursors in a
The a thalassemias are associated with a decrease in a chain synthesis. Hemoglobin H (HbH) disease is a moderately severe form of a thalassemia characterized by the production of 5%-20% of HbH, while a thalassemia trait is a milder form of a thalassemia. In two patients with HbH disease, the ratio of a chain synthesis to fi chain synthesis (a/fl ratio) was decreased in both bone marrow cells an...
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The D antigen content of nucleated red cell precursors in human bone marrow was estimated using autoradiography and 125I-anti-D. D antigen first appeared in the pronormoblast, and the quantity of antigen progressively increased during red cell maturation. Maximal anti-D binding occurred on mature red blood cells. Pronormoblasts, basophilic normoblasts, polychromatophilic normoblasts, and orthoc...
متن کاملHematologic Features of Alpha Thalassemia Carriers
Alpha thalassemia (α-thal) is relatively common worldwide. Most carriers are defective in either one or two alpha globin genes out of four functional ones, with deletions being more common than point mutations. The hematologic features are very important for the selection of the appropriate molecular tests while determining the genotype. The aim of this study was to compare hematologic features...
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The thalassaemias, the commonest monogenic diseases, are a family of inherited disorders of haemoglobin synthesis characterised by a reduced output of one or other of the globin chains of adult haemoglobin. They are likely to pose an increasing health problem for many developing countries during the early part of the new millennium (1). This review focuses mainly on their control and management...
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ژورنال
عنوان ژورنال: Blood
سال: 1976
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v47.6.899.bloodjournal476899